The family, who had immigrated from India in the 1990s and owns a business empire with interests ranging from media to mining, said it was already in talks with "several international prospective buyers."
"As a family, we now believe that the time is right for us to exit our shareholding of the South African businesses which we believe will benefit our existing employees, and lead to further growth in the businesses," said a statement issued by their holding company Oakbay Investments.
Some members of Zuma's family were once employed in Gupta companies, including his son Duduzane who used to be their business partner.
In April the Guptas stepped down from all executive and non-executive positions in Oakbay Investments, following intense scrutiny over their dealings with the government.
The move was also reportedly linked to the closure of the firm's accounts by two major banks.
The extent of the Guptas' political influence came to light early this year when a deputy minister revealed that the family had offered him the position of finance minister before Zuma suddenly removed then minister Nhlanhla Nene in December 2015.
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