Security has been tightened, with shops ordered closed and police conducting door-to-door checks in the upscale Cairo neighborhood where Francis will stay Friday night. His only public Mass is being held at a military-run stadium.
Vatican spokesman Greg Burke said Francis wasn't overly concerned and wouldn't use an armored car, as his predecessors did on foreign trips. Francis insisted on going ahead with the trip even after twin Palm Sunday church bombings killed at least 45 people and a subsequent attack at the famed St Catherine's monastery in Sinai.
The highlight of the two-day trip will be Francis' visit Friday to Al-Azhar, the revered 1,000-year-old seat of learning in Sunni Islam. There, he will meet privately with grand imam Sheikh Ahmed el-Tayeb, and participate in an international peace conference.
Francis has insisted that Christian-Muslim dialogue is the only way to overcome Islamic extremism of the kind that has targeted Christians and driven them from their 2,000- year-old communities in Iraq, Syria and elsewhere in the Middle East.
While condemning extremist attacks against Christians, he has said he is traveling to Egypt as a messenger of peace at a time when the world is "torn by blind violence."
"He has been saying the same words for years, which is all about love and tolerance, but political Islam ruined the world and the most important change should come from Al- Azhar," said John, a 24-year-old Coptic Christian student from Cairo who declined to give his last name because he feared reprisals.
Francis has spent the better part of his four-year papacy seeking to mend the ties, and last year hosted el-Tayeb at the Vatican.
His reciprocal visit will cement the renewed relationship and should help el-Tayeb as he confronts an unprecedented campaign in Egypt's pro-government media accusing Al-Azhar of failing to do enough to combat Islamic extremism.
While Al-Azhar has been increasingly vocal in denouncing attacks and trying to spread an image of moderation, "it is considered by some in Egyptian society to be fundamentally incapable of reforming the religious discourse," said Michele Brignone, managing editor of Oasis, the Italian journal of Christian-Muslim dialogue.
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