Sterling crashed more than 9% to $1.3305, its weakest level since 1985, while the greenback itself slumped below 100 yen for the first time in two-and-a-half years as traders fled to safety.
In the weeks leading up to yesterday's historic vote, there had been widespread warnings that a vote to leave would cause another rout across global markets that would wipe trillions off valuations, just months after a painful China-fuelled sell-off.
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The pound had earlier topped $1.50 following predictions the "remain" group would win but as the Brexit camp posted victories around the country, traders stampeded to put in sell orders.
The dollar slumped briefly to 99.02 yen, the first time it has gone below 100 yen since November 2013, before edging back up slightly. The Japanese unit is considered a safe bet in times of uncertainty and turmoil.
Japan's Finance Minister Taro Aso will hold an emergency news briefing today. He has previously said Japan would closely watch the dollar-yen rate and act accordingly if the yen became too strong, indicating the government could intervene in currency markets.
A flight to safety also saw higher-yielding and emerging market currencies slump, with the Australian dollar down 3.2%, South Korea's won diving 2.4%, Malaysia's ringgit down 2.3% and the Indonesian rupiah shedding 1.7%.
The outcome has upturned expectations, which had been for a tight race narrowly won by the "remain", while bookmakers had said there was a 90% chance of staying in.
But as the shock results rolled in, equity markets went into meltdown.
Tokyo plunged more than 8% in the afternoon, Sydney shed 3.7% and Seoul was 3.5% off. Shanghai sank 1.4% by lunch, while Taipei, Wellington, Manila and Jakarta all saw sharp losses.
Hong Kong tumbled 4.7% by the break with British banking giants HSBC and Standard Chartered both plunging more than 10%.
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