The plane operated by Indonesian carrier Trigana Air lost contact with air traffic control just before 3:00 pm (0600 GMT) today after taking off from Jayapura, the capital of Papua province, the search and rescue agency said.
The ATR 42-300 twin-turboprop plane was carrying 44 adult passengers, five children and five crew on the flight which was scheduled to take about 45 minutes, it said.
But the plane disappeared about 10 minutes before reaching its destination Oksibil, a remote settlement in the mountains south of Jayapura, shortly after it asked permission to start descending to land.
"The plane has been found (by villagers). According to residents, the flight had crashed into a mountain," said the transport ministry's director-general of air transportation, Suprasetyo, who goes by one name.
Officials were still verifying the information from local residents, he said. There was no information about whether anyone may have survived.
Search and rescue teams, police and the military would head to the site as soon as possible Monday, said transport ministry spokesman J. A. Barata.
Captain Beni Sumaryanto, Trigana Air's service director of operations, told AFP that Oksibil was "a mountainous area where the weather is very unpredictable. It can suddenly turn foggy, dark and windy without warning.
"We strongly suspect it's a weather issue. It is not overcapacity, as the plane could take 50 passengers."
Barata said the weather in the area had been "very dark and cloudy".
Trigana Air is a small airline established in 1991 that operates domestic services to around 40 destinations in Indonesia.
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