The "American Hustle" actress had been attached to star in the romantic drama, based on author Graeme Simsion's bestselling 2013 novel of the same name, but she walked away from the film earlier this week.
Now, it has been revealed 57-year-old "Boyhood" director Linklater has also exited the project.
No reason has been given for his departure, but it's the latest setback for the film's producers after The Lego Movie's Phil Lord and Christopher Miller previously dropped out of the adaptation.
Replacements for Linklater and Lawrence have yet to be announced.