Gaza militants on Saturday fired some 250 rockets at Israel, which responded with strikes as a fragile ceasefire again faltered in an escalation that left four Palestinians dead, including a baby killed in disputed circumstances.
The latest flare-up came with Hamas, the Islamist movement that rules the blockaded Gaza Strip, seeking further concessions from Israel under the ceasefire.
Israel said around 250 rockets were fired from the Palestinian enclave and its air defences intercepted dozens of them.
One woman was seriously injured in a rocket strike on the Israeli city of Kiryat Gat, some 20 kilometres (12 miles) from the Gaza border, police said.
A man was also hospitalised in Ashkelon, police said, and spoke of other injuries without providing details. Medics said the woman was 80 and the man was 50.
A house near Ashkelon was damaged while other rockets hit open areas.
The Israeli army said its tanks and planes hit some 120 militant targets.
They included an Islamic Jihad attack tunnel that stretched from southern Gaza into Israeli territory, military spokesman Jonathan Conricus said.
Two multi-storey buildings in Gaza City were destroyed, residents said.
Israel said one of the buildings included Hamas military intelligence and security offices.
Turkey said an office for its state news agency Anadolu was located in the building and denounced the strike.
"We strongly condemn Israel's attack against Anadolu Agency's office in Gaza," President Recep Tayyip Erdogan, an ardent defender of the Palestinian cause, said on Twitter while Foreign Minister Mevlut Cavusoglu said strikes against civilians were "a crime against humanity".
Turkish charity Yardimeli said on social media that the building housing its premises in Gaza was also destroyed, although Turkish officials were not able to immediately confirm the claim.
The Gaza health ministry said Israeli strikes killed a 14-month-old baby and her pregnant mother in addition to two Palestinian men, while 40 were wounded.
It was not immediately clear if the two men were affiliated with militant groups.
Israeli army spokesman Avichay Adraee on Twitter challenged the account of the mother and her baby being killed in an Israeli strike, suggesting they may have died from Palestinian fire.
Adraee did not provide more details and the army refused to comment further.
As the exchange of fire continued, Israeli Prime Minister Benjamin Netanyahu held consultations with security chiefs.
A statement from Hamas ally Islamic Jihad claimed responsibility for at least some of the rocket fire and said it was prepared for more.
Its armed wing distributed a video showing militants handling rockets and threatening key Israeli sites, including Ben-Gurion international airport near Tel Aviv.
Israel said it was closing its people and goods crossings with Gaza as well as the zone it allows for fishermen off the enclave until further notice due to the rocket fire.
Egyptian and UN officials were engaged in discussions to calm the situation, as they have done repeatedly in the past, while the European Union called for an immediate halt to rocket fire from Gaza.
The UN envoy for the Israeli-Palestinian conflict, Nickolay Mladenov, called on "all parties to immediately de-escalate and return to the understandings of the past few months." The United States condemned the rocket attacks on Israel and said Washington fully supported the Jewish state's "right to self-defence against these abhorrent attacks."
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