Details of his alleged affairs with as many as eight women were splashed on Sunday newspapers, after the business man turned politician failed to gag media from publishing the story in a late night urgent court application.
He denied cheating with eight women but admitted to having one affair.
"I had a relationship with only one person and it ended. I dealt with it with my wife. We now have a professional relationship," Ramaphosa told Sunday Times.
The leader of the ANC becomes an automatic candidate for president of the country.
Ramaphosa said the report which is based on leaked email correspondence between himself and the women was a "smear campaign" ahead of the crucial elective conference.
"I have to be prevented at all costs from ascending to the position of president of the ANC. Some have even said it will over their dead bodies," Ramaphosa told Sunday Times.
"I have not committed any crimes, I have not stolen any money, I have not looted state resources. But I am being targeted and smeared," he said.
Pictures of several women purported to be some of his girlfriends had been circulating on social media since Saturday, with the public rebuking his conduct.
But the leader received unlikely support from Julius Malema, the radical leader of Economic Freedom Fighters who was expelled from the ANC in 2012
Malema tweeted: "Ramaphosa, his wife & supporters will have to be extremely strong especially as they move close to the conference, dirty truck on steroids.
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