Twenty-year-old Srikanth overcame South Korea's Wan Ho Son in straight games 21-17 21-18 to set up a clash against Thammasin Sitthikom of Thailand.
Saina, ranked number two in the world, however lost 21-13 12-21 18-21 to eighth seed Juan in a 53-minute match at the Nimitbutr National Stadium here. This was Saina's first defeat to the Singaporean in six encounters.
Saina then slowly started widening the gap and accumulated points at will to pocket the first game.
World number 23 Juan came back strongly in the second round and turned the heat on Saina, moving into the break at 11-7. The China-born Singaporean didn't give Saina much chance to fightback and roared into the contest by pocketing the second game 21-12.
Meanwhile, H S Prannoy was send packing by Indonesia's Wisnu Yuli Prasetyo 21-12 21-19 in the other quaterfinal match of men's event.
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