London Olympics bronze medallist Saina, who is coming back from an ankle injury, dug deep into her reservoir to eke out a 22-24 21-15 21-14 win over world no. 7 Chen in a women singles match that lasted an hour and nine minutes here.
Saina will face China's Chen Xiaoxin in the next round tomorrow.
Young men's doubles pair of Satwiksairaj Rankireddy and Chirag Shetty also crossed the opening hurdle after beating eighth seeded Japanese pair of Takuto Inque and Yuki Kaneko 21-15 21-17 to set up a clash with Chinese Taipei's Liao Min Chun and Su Ching Heng in the second round.
Men's doubles pair of Manu Attri and B Sumeeth Reddy also lost 18-21 21-16 16-21 to Lu Ching Yao and Yang Po Han to bow out of the tournament.
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