World No. 1 Saina survived a scare before prevailing over Thailand's Busanan Ongbumrungphan in women's singles, while Srikanth saw off compatriot and Dutch Open winner Ajay Jayaram in men's singles. Sindhu also advanced after beating Indonesia's Maria Febe Kusumastuti 21-13 21-11.
2012 champion Saina had beaten the Thai girl at the Japan Open this year but those results mattered little as the two squared up in their first game of the tournament.
In men's singles, Srikanth was up against compatriot Jayaram and it was the former who came up with a better performance as he notched up a 21-10 21-14 win in a 32-minute match here.
The India Open champion will next meet the winner of the match between Indonesia's Tommy Sugiarto and Japan's Sho Sasaki.
World No 8 Parupalli Kashyap, however, suffered a 14-21 15-21 loss to former World No. 1 and two-time Olympic silver medallist Lee Chong Wei of Malaysia to bow out of the tournament.
However, it was curtains for 2010 Commonwealth Games champions Jwala Gutta and Ashwini Ponnappa as they lost 19-21 18-21 to seventh seeds Reika Kakiiwa and Miyuki Maeda of Japan in a 45-minute women's doubles match.
In the women's singles match, Saina took time to get off the mark as Busanan dominated the proceedings early on and opened up a 8-4 lead. But Saina clawed back at 9-9. The Indian tried to keep her nose ahead but the Thai girl once again wrested control at 20-18.
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