Alexis Sanchez came back to haunt Arsenal as the Chilean opened the scoring in Manchester United's 3-1 FA Cup fourth-round win to maintain Ole Gunnar Solskjaer's 100 percent record as caretaker manager.
United's winning run under the Norwegian is now eight games in all competitions and his decision to make five changes was vindicated as both Sanchez and the returning Romelu Lukaku had a huge impact.
Lukaku set up both Sanchez's opener and Jesse Lingard's second for the visitors in a two-minute spell just after the half hour mark.
Pierre-Emerick Aubameyang reduced Arsenal's arrears just before half-time and the Gunners had plenty of chances to force a replay, but were denied by Sergio Romero as the rested David de Gea was not missed.
Substitute Anthony Martial then sealed United's place in the last 16 eight minutes from time.
De Gea was the hero when United won 1-0 at Tottenham two weeks ago with a similar counter-attacking style, but Solksjaer believes his side have made progress even from that victory.
"A massive step forward for us performance wise. The structure of the team was miles better compared to Tottenham when we hung in there and David saved us," said Solskjaer.
"Sergio made a fantastic save just after half-time but our structure was miles better. We've worked on that because we need to defend better against better teams."
"It was great to get him 65 minutes tonight. He can only improve and I think he knows that himself."
"The injuries above all when we lost Koscielny, they didn't help us because the rhythm went down and also you need to change different players to play centre-back."
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