More than 19 people were also wounded in the strike that hit the hospital yesterday in Abs in the rebel-held northern province of Hajja, the Paris-based aid agency said.
A Doctors Without Borders (MSF) staffer was among the dead, it said.
The hospital strike was the latest in a series of coalition raids that allegedly hit civilian facilities -- including a school on Saturday where 10 children were killed.
It increased air strikes this month after UN-mediated peace talks between the rebels and Yemen's internationally backed government were suspended.
The coalition's spokesman Tuesday accused the Huthis of using the three months of negotiations to rearm.
"They were deceiving people by this negotiation, to re-organise their force, re-supplying their forces and getting back to fighting," Brigadier General Ahmed Assiri said.
MSF said yesterday's attack was the fourth on one of its facilities in less than a year.
MSF said the hospital's GPS coordinates "were repeatedly shared with all parties to the conflict, including the Saudi-led coalition, and its location was well-known".
Key Saudi ally Washington expressed concern, with a State Department spokeswoman saying: "Strikes on humanitarian facilities, including hospitals, are particularly concerning."
UN Secretary General Ban Ki-moon said he was "deeply disturbed" by the intensification of air raids in Yemen.
Amnesty International said the bombardment "appears to be the latest in a string of unlawful attacks targeting hospitals, highlighting an alarming pattern of disregard for civilian life".
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