The accident happened late Sunday on a highway near the town of Saint-Louis, when the bus burst a front tyre, smashed into the truck and then caught fire.
Fifteen people died on the spot and eight were taken to hospital with injuries, three of whom died yesterday, the state television RTS and the Senegalese Presse Agency (APS) said.
On Friday, 12 people were killed when a bus and a minibus collided in the central region of Kaolack.
Senegal has a grim record for road accidents, a phenomenon blamed on poor driving and vehicle safety.
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