The NSE Nifty also dropped 165.10 points to 7,812.00 ahead of the September derivatives expiry on Thursday.
European market, which is under pressure after the US Fed's decision to hold the rates, was lower with indexes in France, Germany and the UK tumbling by up to 3 per cent.
Gaurav Jain Director of Hem Securities said: "Indices slipped in deep red in line with European peers, China worries, profit-booking and unwinding of positions ahead of September derivative contracts expiry."
After starting on a firm note, the 30-share Sensex cracked under all-round selling and ended the day at 25,651.84, down 541.14 points or 2.07 per cent.
This is the index's lowest closing since September 10.
The NSE Nifty hit a low of 7,787.75 before settling lower by 165.10 points or 2.07 per cent at 7,812.
Traders said that sentiment was also under pressure after Asian Development Bank said that weaker growth in China this year is expected to cause a slowdown in the rest of Asia.
Fresh weakness in the rupee, which fell to Rs 66 against the dollar in the intra-session, too took its toll.
Stocks in the metal space suffered the most after the entire base metal pack retreated at the London Metal Exchange (LME) on mounting global stock amid renewed concerns over slowing growth in China, the biggest consumer of metals.
The big losers in the metal segment included Vedanta, Hindalco and Tata Steel. Coal India, Tata Motors, NTPC, L&T and Axis Bank also lost big time.
Markets in Japan remained shut today for a public holiday and will reopen on Thursday.
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