The 30-share gauge after opening a shade higher, advanced to touch a high of 24,840.77 at the outset before profit- booking in recent gainers took hold, which pulled it down to a low of 24,517.28 and settled at 24,551.17, showing a loss of 253.11 points or 1.02 per cent. The gauge had gained 180.94 points in the previous two sessions.
Some weakness in the rupee too weighed on the sentiment.
Of the 30-share Sensex pack, 22 ended with losses while NTPC ended flat at Rs 127.30.
Shares of Lupin melted the most, falling 7.59 per cent to Rs 1,726.60 after the company received nine observations relating to inadequacy and adherence to operating norms for its manufacturing plant in Goa from the US Food and Drug Administration.
Another pharma firm Pfizer continued to remain under pressure and fell by 3.15 per cent to Rs 1,705.30 amid concerns over ban on their popular drug products.
SBI, Tata Steel, Axis Bank, BHEL, Bharti Airtel, RIL and Maruti Suzuki, ended higher, thus cushioning the fall.
Sectorally, BSE healthcare index took the biggest knock, falling 3.01 per cent, followed by FMCG 1.54 per cent, teck 0.93 per cent, IT 0.85 per cent, auto 0.70 per cent, capital goods 0.22 per cent, power 0.19 per cent and realty 0.09 per cent.
In line with the overall trend, the broader markets also witnessed selling, with the mid-cap index declining 0.79 per cent and small-cap shedding 0.62 per cent.
Foreign investors bought shares worth a net Rs 1,035.63 crore yesterday, as per provisional data.
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