The broader NSE Nifty also failed to maintain the key 8,600-level.
Shares of the country's largest carmaker Maruti Suzuki plunged 1.44 per cent to Rs 4,485.25 despite reporting a 23 per cent jump in profit for June quarter to Rs 1,486.2 crore.
Drug major Dr Reddy's Laboratories plummeted 4.37 per cent to Rs 3,322.85 after its consolidated net profit declined by 80 per cent to Rs 126.3 crore for the June quarter.
"With earnings season failing to sizzle so far and GST poised to face hurdles, stocks faced a confidence crunch and came off the lofty peaks seen yesterday," said Anand James Chief Market Strategist Geojit BNP Paribas Financial Services.
"With a string of firm US economic data and positive surprises on the earnings front, the chances of rate hike, though less likely in July, have also vastly improved, putting global equities under a cloud of caution ahead of FOMC rate decision," he added.
The US Federal Reserve is due to conclude a two-day meeting tomorrow and the Bank of Japan will meet on Friday.
The 50-issue NSE Nifty also dropped by 45 points or 0.52 per cent to end at 8,590.65 after shuttling between 8,644.90 and 8,577.15.
Broader markets, however, depicted a mixed trend with BSE small-cap index falling by 0.69 per cent and mid-cap gaining 0.17 per cent.
Overseas, Japan edged lower as expectations receded with regard to the government's soon-to-be announced fiscal stimulus package. The Nikkei 225 Average ended 1.43 per cent lower. Other Asian indices like China, Hong Kong, Singapore, South Korea and Taiwan firmed up by up to 1.14 per cent.
Sensex pack.
Major losers included ICICI Bank (2.64 pc), Hero MotoCorp (2.12 pc), SBI (1.46 pc), GAIL (1.41 pc), Coal India (1.38 pc), Lupin (1.18 pc), ONGC (1.17 pc), Tata Motors (1.13 pc), Bajaj Auto (1.11 pc) and HDFC Ltd (0.90 pc).
However, Axis Bank rose by 2.85 per cent followed by Power Grid 1.63 per cent, Tata Steel 1.06 per cent, Infosys 0.77 per cent, Wipro 0.77 per cent and NTPC 0.54 per cent.
Among BSE sectoral and industries, realty fell 1.32 per cent followed by auto 1.12 per cent, healthcare 1.11 per cent, bankex 0.73 per cent, oil&gas 0.65 per cent, industrials 0.52 per cent and energy 0.42 per cent, while IT rose by 0.38 per cent followed by teck 0.26 per cent and utilities 0.13 per cent.
The total turnover rose to Rs 4,138.75 crore from Rs 3,866.53 crore yesterday.
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