An AFP correspondent in Douma saw wounded civilians being treated at a makeshift clinic where distressed families were mourning the dead.
The Britain-based Observatory reported "six civilians, including a child, killed by artillery fire in Douma and two others by a shell fired by regime forces in (nearby) Saqba".
A deal reached between rebel backer Turkey and regime allies Russia and Iran earlier this year has created so-called "de-escalation zones" in several parts of the country, including Eastern Ghouta, bringing a measure of calm.
More than 330,000 people have been killed in Syria since the war began in March 2011 with anti-government protests.
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