"There are broad common interests between China and US. There are also some differences between the two countries. Some differences could be sharp. There is no need to deny this," Li, 60, said in his annual press conference here.
"For some time, many people have been talking about differences between the two countries. But at the same time overlooked one very important thing of China last year becoming the top trading partner of the US with two-way trade between the two countries reaching USD 560 billion.
China claims most of the resource-rich SCS, countered by Vietnam, the Philippines, Malaysia, Brunei and Taiwan.
Washington's moves to send naval ships and aircraft in the area to ascertain freedom of navigation has riled China.
As America's China policy has taken the centre stage of the upcoming US Presidential election with contestants vowing to pursue to a more strong policy to contain the Communist giant, Li said Sino-US ties are far deeper to be restricted by differences.
As per difference between the two countries, there are up to 100 various dialogue and exchange mechanism between China and US to address the issues, Li said.
Focusing on his comments on the growing China-US business ties, he said both counties need to act keeping principle of equality and mutual benefit in mind. Currently, they are engaged in negotiations over Bilateral Investment Treaty.
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On relations with Japan, Li said he does not want to see China-Japan ties deteriorate though there are sings of improvement.
He said the relationship is "not fully established and still fragile".
The two sides should adhere to the consensus on historical issues and it is important to match words with actions, Li said, referring to the tensions generated over the disputed islands in East China Sea claimed by both the countries.
China and Russia are each other's biggest neighbours, and there is a comprehensive strategic partnership of coordination in bilateral relations, Li said.
"This relationship is an all-dimensional one," he said, adding that Jinping and Russian President Vladimir Putin have met with each other "quite often".
China has developed its relations with Russia on the basis of mutual respect and mutual benefit and Beijing pursues an independent foreign policy of peace, Li said.
China and Russia can explore their cooperation in the integrated development of oil and natural gas, and introduce greater diversity in bilateral trade, he added.
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