"Three people, a woman and two men, were killed in heavy clashes overnight in which heavy artillery and rockets were used," the source told AFP.
The three were from the Sunni neighbourhood of Bab al-Tebbaneh, whose residents regularly clash with those in the adjacent Alawite district of Jabal Mohsen.
A fourth person wounded in fighting yesterday died of their wounds today.
In addition, two people from Jabal Mohsen were killed on Monday, including one shot by a sniper, the source said.
Syria's rebel opposition is dominated by Sunni Muslims, while the country's President Bashar al-Assad is from the Alawite offshoot of Shiite Islam.
The source said at least 45 people were also wounded in the clashes, which erupted after rocket fire killed eight people last week in the Sunni-majority town of Arsal, which is home to thousands of Syrian refugees.
Arsal is in east Lebanon, near the border with Syria, but tensions in Tripoli often rise in response to events elsewhere.
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