Women who went up a skirt size every decade after their mid-20s had a 33 per cent greater risk of breast cancer after the menopause, say researchers at University College London.
Watching your skirt size from your mid-20s onwards could be a simple way to track weight gain, they told BMJ Open.
Obesity is a known risk factor for cancer, particularly midriff fat.
Professor Usha Menon of the Department of Women's Cancer, who led the study, told BBC News: "If skirt size could be confirmed by others as a good predictor of breast cancer risk in older women, this would be a very simple and easy way to monitor weight gain."
During the three-year follow-up period, 1,090 women developed breast cancer.
The researchers found that a unit increase in UK skirt size every 10 years (for example from 12 to 14) between 25 and post-menopausal age was linked to a 33 per cent increased risk of breast cancer.
Going up two skirt sizes in the same period was associated with a 77 per cent greater risk, they said.
Commenting on the research, Simon Vincent of Breakthrough Breast Cancer said: "We know that 40 per cent of breast cancers could be prevented by changes to lifestyle such as being regularly active and maintaining a healthy weight.
However, the researchers said the study had some limitations - it relied on women being able to accurately recall their skirt size in their 20s.
But if the findings are confirmed, it could give women a simple and easy-to-understand message about the risks of obesity.
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