At least 43 people died in the blasts, and 45 were also wounded in the double bombing outside of Tartus city, which is home to a Russian naval base.
There were no immediate claims of responsibility for the blasts, but the Islamic State group has regularly targeted several of the areas hit on Monday.
Other attacks hit government-held Homs city, an army checkpoint on a road outside Damascus, and a Kurdish security forces checkpoint in Hasakeh city.
Tartus has been largely spared the worst violence of Syria's conflict since it began with anti-government protests in March 2011.
It has become a refuge for many Syrians fleeing the fighting that has displaced over half the country's population.
In the northeast of the country, at least eight people were killed by a bomber on a bike in the city of Hasakeh, which is mostly controlled by Kurdish forces, though the regime is also present.
Hasakeh city has been regularly targeted by the Islamic State group, including in July, when a motorcycle bomber killed at least 16 people outside a bakery in the city.
The IS-linked Amaq news agency reported the blast in Hasakeh, but did not carry any immediate claim of responsibility.
Monday's bombings came after advances by Turkish forces and allied Syrian rebels expelled IS from the last stretch of the Syrian-Turkish border under their control.
The jihadist group has been losing ground to both an alliance of Kurdish and Arab fighters known as the Syrian Democratic Forces and, more recently, a Turkish offensive involving rebels loyal to Ankara.
Al-Zahraa has also been regularly targeted in bomb attacks, including a devastating double bomb blast in February that killed 57 people and was claimed by IS.
State television broadcast images from the aftermath of the blast in Homs, showing rubble strewn on the streets and smoke rising from the charred remains of vehicles.
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