Luis Suarez scored a scintillating double and the returning Lionel Messi set up the winner as Barcelona came from behind to beat Inter Milan in a thrilling contest at Camp Nou.
Lautaro Martinez fired Inter ahead after just two minutes on Wednesday and Antonio Conte's side, mean in defence and ruthless on the break, looked capable of pulling off an historic victory in Group F.
But Suarez broke down the Italians' determined back-line with a stunning volley just before the hour and then finished off a weaving Messi run in the 84th minute to complete a pulsating 2-1 win.
Inter had never beaten Barcelona away from home in the Champions League but were the better side for long spells, particularly in the first half when they should have added to their one-goal lead.
Instead, Barca's deadly duo came up trumps again, Suarez breaking through just as the hosts looked to be running out of ideas before Messi, back from injury, teed up his partner for the decisive second.
Inter play Juventus at home on Sunday, sitting top of Serie A after winning all of their six games so far and on this evidence, they could go far in Europe too.
Barcelona will be wary of the return fixture at the San Siro in December, which could yet decide who wins this group.
"Those are a big three points," said Suarez.
"When you're the number nine, you always try to help the team with goals and assists. Sometimes it doesn't work, but I always work hard. Don't give up in difficult times."
Conte added: "This leaves a bitter taste because we deserved a lot more than we got. But congratulations to Barca, their stars (Suarez and Messi) changed the face of the match."
- Whistles in stands -
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