If confirmed the attack would be the second drone raid under the administration of United States President Donald Trump.
The use of drones has dwindled in Pakistan, where they have proven extremely controversial with the public and rights groups over human rights and sovereignty concerns.
The suspected strike happened yesterday in the Lawara Mandi area of North Waziristan, one of seven so-called tribal districts stretching along the border with Afghanistan, where Pakistan has been battling a homegrown Islamist insurgency for more than a decade and a half.
Local intelligence officials said drones were seen in the area before two missiles hit a house in Lawara Mandi area, believed to be used by the umbrella Taliban militant group, Tehreek-e-Taliban Pakistan.
"There are two militant commanders, Abdul Rehman and Akhtar Mohammad among the dead," an intelligence official told AFP requesting anonymity.
Officials said the missiles could have been fired by US drones, but declined to confirm the origin of the strike.
The previous US strike under the Trump government killed two men riding a motorbike in northwestern Kurram in March.
US National Security Advisor Lieutenant-General HR McMaster made a visit to Pakistan this month after suggesting Washington may take a stronger line with Islamabad, for years seen as an unreliable US ally.
US-led NATO troops have been at war in Afghanistan since 2001, after the ousting of the Taliban regime for refusing to hand over Osama bin Laden following the 9/11 attacks in the United States.
Last year there were only three, including the May 2016 drone strike that killed the then leader of the Afghan Taliban Mullah Akhtar Mansour in southwestern Balochistan province.
In 2013, Amnesty International said the US could be guilty of war crimes by carrying out extrajudicial killings.
Pakistan has also targeted militants with domestic armed drone systems, developed two years ago, but it rarely uses them to strike Taliban groups.
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