"It's natural that we should have such systems," he said, quoted by Syria's official SANA agency yesterday, the same day as Damascus accused Israel of firing several missiles at a military position near its international airport.
"Israel has been committing aggressions on the Arab states surrounding it since its creation in 1948," Assad said in the interview with Venezuelan channel Telesur.
"It is natural for us to negotiate with the Russians now with a view to strengthening (our) systems, whether to face any Israeli threats from the air or the threats of American missiles."
The US military fired 59 Tomahawk missiles at the base overnight on April 6-7 following a suspected chemical attack on a rebel-held town in Idlib province that left 87 dead, including many children.
Washington said the regime base was the launchpad for the attack, a charge Damascus denies.
Russia's military said a day after the attack that Syria's air defences would be boosted.
"To protect Syria's most sensitive infrastructure, a complex of measures will be implemented in the near future to strengthen and improve the effectiveness of the Syrian armed forces' air defence system," said spokesman Igor Konashenkov
Assad also said that no country which had aided the Syrian opposition should be allowed to take part in Syria's post-war reconstruction.
"All the states which stood against the Syrian people and took part in the destruction and sabotage will never take part in rebuilding Syria. That is final," he said.
International organisations estimate that reconstructing Syria, devastated by a six-year war that has left over 320,000 dead, will cost upwards of USD 300 billion.
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