"There is a certain worry or concern about the state of international relations, because if you put tariffs against what are your allies, one wonders who the enemies are," said Draghi.
"We are convinced that disputes should be discussed and resolved in a multilateral framework," he said, warning that "unilateral decisions are dangerous".
Trump's impromptu announcement last week that he intended to slap 25 percent taxes on steel imports and 10 percent on aluminium revived the spectre of a trade war between the United States and major trade allies like Canada or the European Union.
Draghi cautioned that the "rising protectionism" could harm growth in the eurozone.
"Downside risks relate primarily to global factors including rising protectionism and developments in foreign exchange and other financial markets," Draghi told reporters after an ECB governing council meeting in Frankfurt.
Draghi also unveiled the bank's latest growth and inflation projections.
He said the ECB had lifted its 2018 growth forecast for the eurozone from 2.3 to 2.4 percent, underscoring a bright outlook despite the political risks on the horizon.
Its inflation projections were also unchanged for 2018 at 1.4 percent, but slightly lowered for 2019 from 1.5 to 1.4 percent.
The bank still expects inflation to hit 1.7 percent in 2020 -- inching closer to the ECB's target of just under 2.0 percent.
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