The accident happened at Pali on Jaunpur-Bhadohi road, police said.
Nagendra Yadav, aged 28, and Chandra Shekhar (30) were riding a motorcycle when it skidded on the road, they said.
As they were lying injured on the road, a speeding truck mowed them down, police said.
The truck driver sped away after the accident, they said.