Karp said that he will leave by the end of this year and chief operating officer Jeff D'Onofrio will take his place at the helm of Tumblr.
"I beg you to understand that my decision comes after months of reflection on my personal ambitions, and at no cost to my hopefulness for Tumblr's future or the impact I know it can have," he said in a copy of a letter to employees that he posted online.
"We made it really, really simple for people to make a blog and put whatever they want on it. Stories, photos, GIFs, TV shows, links, quips, dumb jokes, smart jokes, Spotify tracks, mp3s, videos, fashion, art, deep stuff," reads a self-description on the website.
Yahoo acquired Tumblr in May 2013 for $1.1 billion, as part of an effort to better connect with younger online users.
Meanwhile, Verizon's online unit Oath -- which includes the AOL and recently acquired Yahoo brands -- is cutting several hundred jobs as part of a reorganization, a source familiar with the move said earlier this month.
The move represents a second round of cuts at Oath since the USD 4.5 billion acquisition of Yahoo in June.
"We're about four months post-close of Verizon's acquisition of Yahoo, and we've made these changes to our team to further align our global organization to our 2018 roadmap," Oath said in a statement at the time.
Media reports said the move would eliminate an estimated 560 jobs in different Oath business units such as advertising and engineering.
Verizon has so far maintained the Yahoo brand, which has some one billion users worldwide for its email, news and other services.
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