The goal of the first-ever high-level General Assembly meeting is to spur international action to ensure that the disabled can contribute to the global economy.
"Far too many people with disabilities live in poverty (and) too many suffer from social exclusion" and are denied access to education, health care, and social and legal support, Ban said.
The World Health Organization said a huge increase in hearing aids, glasses and wheelchairs could improve the lives of hundreds of millions of people. But the disabled have other hurdles to overcome, including discrimination and stigma.
He urged the international community to make it possible so that every single person with disabilities "will be freer" to pursue their lives and dreams.
General Assembly President John W Ashe stressed the importance of a new global commitment.
"Given the size of such a marginalized group, the onus is on us all to ensure that any future Sustainable Development Goals include the disabled," he said, referring to new UN goals being debated for 2015 to 2030 to fight poverty and promote equality.
Today's meeting is the prelude to the annual UN gathering of presidents, prime ministers and monarchs, which starts tomorrow.
For the disabled, who represent about 15 per cent of the world's population, today's meeting is a milestone. Speakers also include US Secretary of State John Kerry.
"We are excited about what's going to happen," said Daniela Bas, director of the UN Division for Social Policy and Development, who has been a paraplegic since the age of 6.
According to WHO, 360 million people worldwide have moderate to profound hearing loss, but only 10 per cent have access to hearing aids.
Some 200 million people need glasses or low-vision devices but have no access to them, and only between 5 to 15 per cent of the 70 million people who need wheelchairs have access to one.
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