The estimate of how much money will be needed is based on an upwardly revised assessment that Guterres plans to formally present tomorrow. It includes a new estimate there will be at least 3.6 million Syrian refugees in the region by the end of the year.
There are now 2.9 million Syrian refugees registered in the region, with 100,000 more added each month.
"Failing to provide enough humanitarian support for Syrian refugees by the end of 2014 could result in dramatic consequences for refugees and the stability of the entire region, including a serious security threat to Lebanon," Guterres said.
"We have a situation of heightened volatility in the region, a spillover of the conflict into Iraq, and continued outflows of refugees into neighbouring countries grappling with very complex security and humanitarian issues," he said.
Without more money, Guterres warned there will be increased numbers of women and children at risk of violence, exploitation and abuse, and reduced food rations and increased acute malnutrition rates.
The agency estimates some 2.4 million people will need extra support to prepare for winter, and more help will be needed for 860,000 refugees now living outside of camps in sub-standard shelter.
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