"A vehicle close to a militant compound was the target of the strike in the Shonkrai Narai village of South Waziristan," an official said about the airstrike carried out by a CIA-operated drone.
South Waziristan is a semi-autonomous tribal area along Pakistan-Afghanistan border. The area is believed to have heavy presence of Sajna faction of the Taliban militants.
The official confirmed the deaths, but did not provide details regarding the identities of the deceased, The Express Tribune reported.
The drone strike comes after a long halt as North Waziristan has been the main target of American drone strikes.
At least five militants were killed when a US drone fired two missiles at a compound in North Waziristan, officials had said on September 1.
Earlier this week, security forces imposed a curfew in South Waziristan after a convoy came under attack which left one dead and injuring five security personnel.
Meanwhile, the army is continuing its operation in the nearby Shawal Valley where a ground offensive was launched last month.
More than 85 people have been killed in drone strikes in Pakistan.
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