The decision to expand research into marijuana's medical potential could pave the way for the drug to be moved to a lesser category.
Heroin, peyote and marijuana, among others, are considered Schedule I drugs because they have no medical application; cocaine and opiates, for example, have medical uses and, while still illegal for recreational use, are designated Schedule II drugs.
The Drug Enforcement Administration said the agency's decision came after a lengthy review and consultation with the Health and Human Services Department, which said marijuana "has a high potential for abuse" and "no accepted medical use."
Advocates have long pushed for the federal government to follow suit.
"If the scientific understanding about marijuana changes and it could change then the decision could change," DEA acting administrator Chuck Rosenberg wrote in a letter to the governors of Rhode Island and Washington, who sought the review of marijuana's classification in 2011.
"But we will remain tethered to science, as we must, and as the statute demands. It certainly would be odd to rely on science when it suits us and ignore it otherwise."
The Food and Drug Administration said agency officials reviewed more than 500 studies on the use of medical marijuana, identifying only 11 that met the agency standards for "legitimate testing." For various reasons, none of the trials demonstrated "an accepted medical use," the agency concluded.
The FDA last evaluated marijuana for medical use in 2006 and said in its latest review that the available research "has progressed," but does not meet federal standards of safety or effectiveness.
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