The US-led agreement is a major part of President Barack Obama's foreign policy shift toward Asia but has been snagged by disagreements between countries on market access, especially for agricultural products, environmental protections and intellectual property.
Washington had said it hoped the trade agreement would be completed by the end of the year.
After four days of meetings in Singapore, ministers issued a statement today saying that "substantial progress" had been made on finalizing the Trans-Pacific Partnership. It said that they had identified "potential landing zones" for most of the outstanding issues and would meet again next month.
Elms, who follows the negotiations, said she expected a deal to be finalized in March. Others have predicted similar.
Negotiators from the 12 countries are aiming to reduce tariffs on goods and services to close to zero. They are also trying to ensure that foreign companies operating in those markets have a level playing field with state-owned ones, and that their products are not counterfeited.
The block includes developing countries with large state-owned industries such as Vietnam and Malaysia as well as rich nations including the United States and Japan.
Any deal will have to be passed by the US Congress, which might demand changes to the text.
Non-governmental organizations have also been seeking to influence the agreement to get a better deal for poor.
They fear that cost of medicines may rise in countries such as Vietnam because US pharmaceutical companies are pressing for long periods of patent protection, slowing the release of generic versions of drugs.
The talks in Singapore followed a World Trade Organization summit in Bali last week at which the organization's 159 member economies agreed to cut customs red tape. It was the first WTO deal since the global trade body was formed in 1995.
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