The attack by four A-10 attack planes and two AC-130 gunships was carried out Saturday at a site near Deir el-Zour and al-Hasakah but not reported until Monday.
It followed a similar assault on November 15 that destroyed 116 tanker trucks and is part of a broader air campaign, dubbed Operation Tidal Wave II, designed to cripple the militants' oil producing, refining and distribution system.
Until the November 15, the US had refrained from attacking oil trucks, fearing it could cause unintended civilian deaths.
In its daily summary of airstrikes, the US-led military coalition said today that 283 vehicles had been struck in eastern Syria on November 21 but did not elaborate.
Army Col Steve Warren, a US military spokesman in Baghdad, said in an email exchange that the vehicles were oil tanker trucks and that the attack was part of the broader oil targeting campaign.
US aircraft dropped warning leaflets and made strafing runs in the area to persuade the civilian drivers of the tanker trucks to abandon their vehicles before the bombing began, Warren said, adding that the US believes no civilians were injured or killed.
Russia also has begun targeting the Islamic State's oil infrastructure with airstrikes, including attacks on tanker trucks.
The US-led coalition has targeted oil infrastructure occasionally in the past, including a heavy attack last month on Syria's Omar field near the town of Deir el-Zour that hit refineries, command and control centers and transportation nodes.
