At the close of play, Vidarbha were comfortably placed at 431 for six, with an overall lead of 501 runs.
Resuming on 77 for one, overnight batsman Fazal, starting at a personal score of 51, went on score a 209-ball 119 that included 15 hits to the fence.
Wasim Jaffer (58) and Ganesh Satish (65) then contributed with half-centuries each, while lower-order batsman Wankhade's quickfire 107 that came off just 94 deliveries, studded with six boundaries and five sixes, put the hosts in the driver's seat.
With Vidarbha already having taken a first-innings lead, they have all but made it to the semifinals.
For Kerala, Jalaj Saxena chipped in with three for 106.
Brief scores:
Vidarbha: 246 & 431/6 in 124 overs (Faiz Fazal 119, Apoorv Wankhade 107, Ganesh Satish 65, Wasim Jaffer 58; Jalaj Saxena 3/106).
Kerala 1st innings: 176 all out.
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