The show had been scrapped in 2014 but then brought back in development again earlier this year, reported Ace Showbiz.
D'Onofrio's version of the Wizard of Oz is described as "the enigmatic leader of Emerald City.
A man of science in a world of magic, he rules through inspiration, fear and a tenous accord with the grand witches."
Dubbed a "modern and dark re-imagining of" the classic tale "The Wizard of Oz", the upcoming series itself follows 20-year-old Dorothy Gale who is swept up into the eye of a tornado and "transported to another world, a mystical land in great peril, where an all-powerful Wizard has outlawed magic and rules over the many kingdoms.
Adria Arjona, who has guest starred on "Person of Interest" and had a role on "True Detective" season 2, has been cast as Dorothy.
David Schulner is tapped as showrunner in addition to serving as executive producer along with Shaun Cassidy.
"The Cell" helmer Tarsem Singh will direct the drama, which has received a 10-episode, straight-to-series order from NBC.
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