If Senate Democrats can amass 41 votes in favor of the deal, they could block passage of a congressional resolution to disapprove of the deal.
If that doesn't happen and the Republican-led Senate votes to disapprove of the deal, President Barack Obama has vowed to veto it. Democrats then would need 34 votes four more than they have now to prevent a congressional override of the presidential veto.
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He wouldn't predict the success of getting to 34 or 41 votes, but said some of the 14 undecided Democrats likely would announce their decision before Congress returns from its August recess.
Republicans are unanimously against the deal which provides sanctions relief to Iran in exchange for constraints on its nuclear program. Two Senate Democrats also have announced their opposition.
In an opinion piece in The News Journal of Wilmington, Delaware, Carper said the deal was good for America and allies, including Israel.
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