The 2005 movie featured Vince and Owen Wilson as divorce mediators Jeremy Grey and John Beckwith, who frequently turn up uninvited to weddings in order to meet women.
Isla portrayed Vince's possessive onscreen lover, Gloria, and the Australian actress said that the gang will be getting back together for more mischievous fun - if a recent chat with Vince is any indication, reported Digital Spy.
"I bumped into Vince Vaughn at a party and he said that apparently we're going to be making a sequel," she said during an appearance on US breakfast show "Today".
Officials at production firm Tapestry Films and distributor New Line Cinema have yet to comment on news of a sequel.
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