Mohammad Abbas then removed Kieran Powell to a catch at the wicket in the 14 overs the home side faced in their second innings before the close of play. They will resume on the fourth morning at 40 for one, still needing 41 more runs to erase the first innings deficit with opener Kraigg Brathwaite and Shimron Hetmyer at the wicket.
Having survived an optimistic appeal for LBW against his West Indian counterpart Jason Holder the ball before, Misbah attempted to pull out of the way of the next delivery which lifted sharply and came off the glove for Shai Hope to gleefully hold the catch at second slip.
His surprise demise broke a brisk 57-run partnership with Asad Shafiq after earlier adding 98 with Ali, the opening batsman reaching a painstaking 13th Test century in mid- afternoon before he was caught at the wicket off Devindra Bishoo for 105, the leg-spinner's third success of the innings.
Ali's marathon effort occupied seven-and-a-half hours during which he faced 278 deliveries, stroking just nine boundaries in an innings characterised by considerable discipline and patience.
Off the very last ball of the afternoon session, Shafiq was ruled leg-before to the miserly Holder, although Pakistan's tail wagged to the tune of another 64 runs after tea, Yasir Shah being last out to Gabriel, who led the home side's bowling effort with four for 81 off 32 overs.
Those eventful sessions after lunch were in direct opposition to the tedium of the morning, where 54 runs came off 26 overs as Ali and Misbah batted with almost exaggerated care on a pitch showing increasing signs of wear and offering disconcertingly variable bounce.
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