Researchers found that women are more sensitive to negative images compared to men, which may explain why women are more likely to suffer from depression and anxiety.
"Greater emotional reactivity in women may explain many things, such as their being twice as likely to suffer from depression and anxiety disorders compared to men," said lead author Adrianna Mendrek, a researcher at the Institut universitaire en sante mentale de Montreal.
For the study, 46 healthy participants - including 25 women - viewed images and said whether these evoked positive, negative, or neutral emotions.
At the same time, their brain activity was measured by brain imaging. Blood samples were taken beforehand to determine hormonal levels (eg, estrogen, testosterone) in each participant.
The researchers found that subjective ratings of negative images were higher in women compared to men. Higher testosterone levels were linked to lower sensitivity, while higher feminine traits (regardless of sex of tested participants) were linked to higher sensitivity.
"This last point is the most significant observation and the most original of our study," said co-author Stephane Potvin, a researcher at the Institut universitaire en sante mentale.
The amygdale is a region of the brain known to act as a threat detector and activates when an individual is exposed to images of fear or sadness, while the dmPFC is involved in cognitive processes (eg, perception, emotions, reasoning) associated with social interactions.
"It is possible that women tend to focus more on the feelings generated by these stimuli, while men remain somewhat 'passive' toward negative emotions, trying to analyse the stimuli and their impact," said Potvin.
This connection between the limbic system and the prefrontal cortex appeared to be modulated by testosterone - the male hormone - which tends to reinforce this connection, as well as by an individual's gender.
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