The 17 countries agreed "to implement a nationwide cessation of hostilities to begin in a target of one week's time," said US Secretary of State John Kerry after extended talks co-hosted by Russian Foreign Minister Sergei Lavrov.
The International Syria Support Group also agreed "to accelerate and expand the delivery of humanitarian aid beginning immediately".
"Sustained delivery will begin this week, first to the areas where it is most urgently needed... And then to all the people in need throughout the country, particularly in the besieged and hard to reach areas," said Kerry.
The bombardments have forced 50,000 people to flee, left the opposition virtually encircled and killed an estimated 500 people since they began on February 1 -- the latest hellish twist in a war that has claimed more than 260,000 lives.
Kerry said talks between rebels and the regime would resume as soon as possible, but warned that "what we have here are words on paper -- what we need to see in the next few days are actions on the ground."
"When the whole world sees whether today's agreements are kept and implemented -- by the Assad regime and the Syrian opposition, by Hezbollah and opposition militias, and also by Russia," he said.
The atmosphere going into the talks had been gloomy, with Russian Prime Minister Dmitry Medvedev even warning of a "new world war" if Gulf nations sent in troops to support the rebel opposition.
But the working group emerged with a document that showed a surprising level of cooperation between the key players, despite rising tensions over Moscow's bombing campaign.
Kerry said the cessation of hostilities -- an intentionally more tentative phrasing than a full ceasefire -- would apply to all groups apart from "the terrorist organisations" of the Islamic State (IS) group and Al-Qaeda affiliate al-Nusra.
A UN task force, co-chaired by Russia and the US, will work over the coming week "to develop the modalities for a long-term, comprehensive and durable cessation of violence," Kerry said.
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