Named "Naia" by scientists, her skeleton is among the oldest known and best preserved in the Americas.
She was discovered by a team led by the Mexican government's National Institute of Anthropology and History and supported by the Washington-based National Geographic Society.
Naia's remains were found in 2007, submerged in an underwater cave along with the bones of saber tooth tigers, giant sloths and cave bears, some 135 feet (41 meters) below sea level.
Melting glaciers caused sea level rise that covered the pit with water for the last 8,000 years.
The girl was aged 15 to 16 and may have slipped into what appeared to her, and to the animals who met the same demise, to be a watering hole.
Her pelvis appears to have broken on impact, suggesting she died quickly after her fall, said Jim Chatters, an archeologist and forensic anthropologist in Bothell, Washington.
Her skull shows she had a small, narrow face, wide-set eyes, a prominent forehead and teeth that jutted outward.
But a genetic marker found in the girl's rib bone and tooth shows that her maternally inherited lineage was the same as that found in some modern Native Americans.
The report in the journal Science yesterday suggests she descended from people who migrated from Asia across the Bering Strait, over a land mass that was known as Beringia.
"What this study is presenting for the first time is the evidence that paleo-Americans with those distinctive features can also be directly tied to the same Beringian source population as contemporary Native Americans," said Deborah Bolnick, an assistant professor at the University of Texas at Austin.
"I used to be one of those advocates of multiple immigration events," said Chatters, an archeologist who is best known for his work on Kennewick Man, a 9,800-year-old skull and skeletal remains found in the US state of Washington.
Naia is the sixth oldest human found in the Americas, said Chatters.
Future research aims to sequence her nuclear DNA, which should reveal more details about her ancestry.
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