Merck, Pfizer and Syndax to collaborate for ovarian cancer drug research

 
“This collaboration with Syndax adds a new dimension to our quest to pursue combination immuno-oncology regimens based on compelling preclinical rationale and the potential to generate clinical results superior to those achieved with either agent alone,” said Dr Mace Rothenberg, senior vice president of clinical development and medical affairs and chief medical officer for Pfizer Oncology. 
 
“Combination therapy is the next frontier in immuno-oncology and a key strategy for the alliance. Avelumab as a monotherapy has already shown promising early activity in ovarian cancer in a phase Ib trial, and through our ongoing research and this collaboration with Syndax, we will hopefully be able to make a real difference to women fighting this complex cancer,” added said Dr Luciano Rossetti, head of global research & development of the biopharma business of Merck.

 
Dr Briggs Morrison, Syndax’s chief executive officer, commented, “The continued interest from leading companies in investigating the potential of entinostat in combination with checkpoint inhibitors reflects positively on the potential mechanism of action of the molecule, and also reinforces our clinical strategy to explore entinostat for the benefit of patients across a broad range of solid tumor indications.”