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AstraZeneca Pharma India Ltd on Tuesday said it has received permission from India's drug regulator to market Durvalumab solution for infusion used in cancer treatment for an additional indication. The company has received permission from the Central Drugs Standard Control Organisation, Directorate General of Health Services, to import for sale and distribution of Durvalumab solution for infusion of strengths 120 mg/2.4 ml and 500 mg/10 ml (brand name Imfinzi) for an additional indication, AstraZeneca Pharma said in a regulatory filing. Through this approval, Durvalumab in combination with carboplatin and paclitaxel is indicated for the first-line treatment of adults with primary advanced or recurrent endometrial cancer who are candidates for systemic therapy, followed by maintenance treatment with Durvalumab as monotherapy in endometrial cancer which is mismatch repair deficient (dMMR). The receipt of this permission paves way for the marketing of Durvalumab solution for infusion 1
India had a largely inconsistent growth in clinical research related to cancer since 2001, despite a strong economic growth, suggesting that development could be a contributing factor towards disparities among the low and middle-income countries in cancer research, according to a new study. Cancer cases and deaths are projected to surge in the coming decades with low and middle-income countries expected to bear a disproportionate burden. However, researchers, including those from the the Latin American Cooperative Oncology Group, said that clinical trials of cancer are disproportionally concentrated in high-income countries, even as previous evidence suggests an increase in trials among low and middle-income nations. The study, published in the journal 'CANCER', looked at disparities in the numbers and complexity of clinical trials over time and according to economic changes. Datasets from World Bank and ClinicalTrials.gov were analysed. Between 2001 and 2020, a total of 16,977 can