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More than a dozen states have sued the Trump administration over its rollback of vaccine recommendations for children, calling the move an illegal threat to public health. The states on Tuesday argue that the Centres for Disease Control and Prevention put children's lives at risk when it announced last month that it would stop recommending all children get immunised against the flu, rotavirus, hepatitis A, hepatitis B, some forms of meningitis and RSV. Under the new guidance, which was met with criticism from medical experts, protections against those diseases are recommended only for certain groups deemed high risk or when doctors recommend them in what's called "shared decision-making." The new vaccine recommendations ignore long-standing medical guidance and will make states have to spend more to protect against outbreaks, the states, including Arizona and California, said. "The health and safety of children across the country is not a political issue," Arizona Attorney General
Getting the second Covid jab on the same arm as the first one or on the opposite arm could influence the body's immune response generated against the SARS-CoV-2 virus, new research from Germany says. Those who got jabbed on the same side, or ipsilaterally, generated more antibodies against the Covid-causing pathogen than those who got jabbed on the opposite side, or contralaterally, the study from Saarland University and other German institutes found. Further, median levels of infection-fighting CD8 T-cells generated in response to the spike-protein of the pathogen were found to be significantly lower in those contralaterally vaccinated. CD8 T-cells destroy virus-infected cells and render protection against severe disease. Consequently, after contralateral vaccination, fewer individuals (43 per cent) were found to have detectable levels of CD8 T-cells than after ipsilateral vaccination (67 per cent), the study published in the journal eBioMedicine said. Individual doses of two-dose
Human body's natural process of removing old and damaged cell parts could be harnessed to treat infections like tuberculosis (TB), reducing reliance on antibiotics, according to a new study. Researchers at the Francis Crick Institute, UK, investigated genes important for bacteria to evade autophagy, a self-destruction mechanism cells resort to when stressed. Their study is published in Nature Microbiology. According to the study, from induced pluripotent stem cells, a kind of specialist stem cells and are able to become any cell type in the body, the scientists engineered macrophages, or human immune cells. Following this, they disabled these macrophages from performing autophagy using genome editing tools. The cells were then infected with Mycobacterium tuberculosis, bacteria causing TB. The scientists found that the infection took hold, replicating more within the edited macrophages and causing mass host-cell death. The results evidence the role of autophagy in controlling ...