Reddy, 80, had been undergoing treatment for neurology-related problems and the end came at 5 AM.
He is survived by wife and four sons.
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He served as state minister and legislator in his long political career spanning several decades.
Reddy took a tough stand against Naxalities and had survived an attack on his life by the extremists in 2007.
Several senior leaders including TDP chief N Chandrababau Naidu condoled the death of Janaradhan Reddy.
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