"Regime military aircraft fired at least two missiles at a souk (market) in Mayadeen, killing at least 23 civilians including eight children and five women," Rami Abdel Rahman, head of the Syrian Observatory for Human Right said.
He said 50 others were wounded in the raids on Mayadeen yesterday, located in Syria's oil-rich Deir Ezzor province and held by jihadists from the Islamic State group.
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On Sunday, the Observatory reported that IS had shut down playgrounds in Mayadeen "under the pretext that there was mixing between men and women bringing their children to play".
The ultra-radical organisation has imposed its extreme interpretation of Islam in areas under its control across swathes of Syria and Iraq.
Regime air strikes also killed four civilians in Kfarbatna, a town in the rebel bastion of Eastern Ghouta near Damascus, the Observatory said.
And two people died inside the capital itself when opposition fighters fired shells onto a district, Syria's official news agency SANA said.
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