Cavusoglu said Turkey would provide every kind of support that may be necessary to "cleanse" Turkey's border with Syria of the extremists.
The death toll from Saturday's attack increased to 54 on Monday, after three more victims died in hospital, the state-run Anadolu Agency reported. Nearly 70 others were wounded.
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There was no immediate claim of responsibility, but officials have said it appears to be the work of the Islamic State group, accusing it of trying to destabilise the country by exploiting ethnic and religious tensions. It was the deadliest attack in Turkey this year.
Authorities were trying to identify the attacker, who President Recep Tayyip Erdogan said was aged between 12 and 14.
Responding to a question on reports that Turkish-backed Syrian opposition forces may launch an operation to free an IS-held town from Turkish territory, Cavusoglu said: "Our border has to be completely cleansed of Daesh. It's natural for us to give whatever kind of support is necessary," He was using an Arabic name for the IS group.
"(IS) martyred our ... Citizens. It is natural for us to struggle against such an organization both inside and outside of Turkey," he said.
Cavusoglu said Turkey had become a main target for the IS group because of measures it has implemented to stop recruits from crossing into Syria to join the fighting, as well as hundreds of arrests of IS suspects in Turkey.
He said Turkey had also become a top target because of statements by Turkish President Recep Tayyip Erdogan who has said the extremist group did "not represent Islam."
"Turkey has always been Daesh' primary target, because Turkey has dried out the source of Daesh's supply of foreign fighters, rather, it has stopped them from crossing into Syria," he said.
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