He said the country's armed forces have regained control of more than 3,000 square km (1,158 square miles) since the beginning of this month.
The fall of Izium marked Russian forces' worst defeat since they were were pushed back from the capital Kyiv in March, as thousands of Russian soldiers left behind ammunition and equipment as they fled.
"I believe that this winter is a turning point, and it can lead to the rapid de-occupation of Ukraine," Zelensky said in comments to a political forum published on his website late on Saturday. "We see how they (occupiers) are fleeing in some directions. If we were a little stronger with weapons, we would de-occupy faster."