The Institute for Supply Management said on Wednesday its index of national factory activity dropped to 56.6 last month, its lowest level since June. A reading above 50 indicates expansion.
Analysts have been warning US factories could feel a chill from soft demand in the global economy and from recent strength in the US dollar, and the ISM data could be an indication of this.
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A separate report from a major payrolls processor showed US private employers added 213,000 jobs in September, just above economists' expectations.
"It still looks as though overall GDP growth in the third quarter was around 3.5 per cent," said Paul Dales, an economist at Capital Economics in London.
US Treasury yields fell as data from the US, Europe and Asia showed the factory sector faltering, while the dollar slipped. US stocks, which opened lower on concerns the first diagnosis of Ebola in the US could curb air travel, extended losses after the manufacturing data was released.
The slowdown in US factory growth last month follows an August reading that had been the strongest since March 2011, leading some analysts to downplay the significance of the September reading.
"This is still a very strong reading by historical standards," said Ian Shepherdson, an economist at Pantheon Macroeconomics.
Separately, the Commerce Department said US construction spending fell in August, hit by weaker private spending outside the housing sector and a pullback in public investments.
Construction spending dropped 0.8 per cent to an annual rate of $960.96 billion. Economists polled by Reuters had forecast construction spending increasing 0.5 per cent in August.
The surprise decline was largely due to a 1.4 per cent drop in money spent on private non-residential construction, although outlays fell across the board with state and local construction down 0.9 per cent.
Private spending on housing fell only 0.l per cent in August, which is unlikely to unmoor expectations of an ongoing recovery in the housing market.
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