However, there was some buying in broader markets with the mid and smallcap indices gaining 0.4% each.
The rupee is not far from its record low of 58.98 hit last week, trading at 58.68 versus 57.87/88 at Monday's local close.
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MSCI's broadest index of Asia-Pacific shares outside Japan fell 0.2%, with Chinese and Australian bourses leading the declines.
South Korean shares bucked the trend and rose 0.9% while Southeast Asian shares were also mostly higher.
Japan's benchmark Nikkei stock average gave up early gains and fell 0.2%, swinging from Monday's 2.7% rise.
Meanwhile, European shares opened in the red ahead of the start of the Fed meet later in the day, CAC, DAX and FTSE gave off 0.1-0.5% in opening trades.
Back home, Consumer Durables, Bankex, Auto, FMCG, PSU and Capital Goods indices slipped 0.1-0.8% while Realty, Teck, It, Metal, Oil & Gas, Health Care and Power indices logged gains between 0.04-0.7%.
The only gainers among the Sensex-30 were Hindalco, infosys and Tata Power which gained 1% each along with Reliance Industries, Bharti Airtel, Bajaj Auto, Hero MotoCorp, Wipro and Tata Steel gaining 0.5-0.8%.
Among the draggers were Tata Motors, ICICI Bank, NTPC, Gail India, HDFC Bank and HDFC down 1-1.5%.
The other notable losers were ITC, Dr Reddys Lab, Cipla, L&T and ONGC down 0.4-0.9%.
In individual stocks, Venus Remedies surged 6.3% to Rs 291 after the company said it has received patent from Mexico for its novel antibiotic product Potentox.
VA Tech Wabag gained 3.3% at Rs 455 after the company in a joint venture with Pratibha Industries has won an Rs 262 crore order from Melamchi Water Supply Development Board, Nepal.
Panacea Biotech is trading higher by 10% to Rs 119, extending its previous day’s 20% rally on BSE, on back of heavy volumes.
The market breadth was positive owing to the strength in broader markets. 1,021 stocks advanced while 946 stocks declined on BSE.
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